Q580 BASIC HUMAN GENETICS (3 cr.)
General genetics and consent of the instructor. An introduction to the genetics of human traits and heritable diseases. Emphasis will be on general aspects of eukaryotic genetics as it applies to humans, but some prokaryote genetics will be included for comparison.
Q604 GENETIC COUNSELING COMMUNICATION TECHNIQUES (4 cr.)
Genetic counseling models, methods and communication skills; professional issues related to client interactions. Practice-based learning through role play, analysis of genetic counseling case studies, and other class interactions.
Q606 FOUNDATIONS IN GENETIC COUNSELING (4 cr.)
Introduction to the principles and practice of genetic counseling. Topics include genetic counseling techniques, prenatal diagnosis counseling, pediatric/adult counseling, and support services.
Q608 INTRODUCTION TO GENETIC COUNSELING RESEARCH (1 cr.)
An overview of topics related to the development of genetic counseling research projects. Topics will include library tools, project development, research ethics, IRB, basic statistics, and manuscript preparation. Each student will develop a research proposal.
Q609 PRACTICAL CANCER GENETIC COUNSELING (2 cr.)
Overview of hereditary cancer syndromes, genetic risk assessment for personal and family history of cancer, genetic counseling approaches, and testing issues.
Q610 CLINICAL GENETICS PRACTICUM (3 cr.)
Consent of the instructor. Methods for obtaining medical and family histories, approaches to evaluation of individuals and families with genetic disorders, and techniques for providing genetic counseling. May be repeated once for credit.
Q611 GENETIC ANALYSIS LABORATORY (2 cr.) [Currently inactive]
Consent of the instructor. Computer storage and retrieval of family data. Use of programs for genetic analysis. Includes analysis of twins, families of twins, and genetic linkage and segregation.
Q612 MOLECULAR AND BIOCHEMICAL GENETICS (3 cr.)
Molecular and biochemical aspects of gene function in various genetic disorders. Emphasis on the DNA lesion when known, on aberrations in the metabolic pathways, and on structural defects. Discussion of hemoglobinopathies, phenylketonuria, storage diseases, and other conditions.
Q613 MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY (2 cr.)
The student will learn to review and interpret laboratory results for clinical diagnostic genetic testing.
Q614 PSYCHOLOGICAL ASPECTS OF GENETIC COUNSELING (3 cr.)
Introduction to theory and research in the field of Genetic Counseling. Topics include risk assessment, attitude assessment, and decision making. The social, ethical and legal aspects of the delivery of genetic services are also covered. Prerequisites are one course in introductory or abnormal psychology.
Q615 PRENATAL DIAGNOSIS PRACTICUM (3 cr.)
Training in prenatal genetic counseling, counseling referrals may include advanced maternal age, abnormal prenatal screening, abnormal ultrasound, or other pregnancy complications.
Q616 SPECIALTY CLINICS PRACTICUM (2 cr.)
An overview of the long-term management of patients living with a variety of genetic conditions. Students may provide genetic counseling while in these clinics.
Q617 GENETIC COUNSELING PRACTICUM (var.)
Training in general genetic counseling. Counseling referrals may include recurrent miscarriage, family history of a genetic condition, preconceptional counseling, and teratogen exposures.
Q618 PRACTICAL CARDIOVASCULAR GENETIC COUNSELING (1 cr.)
Overview of hereditary cardiovascular conditions, genetic risk assessment for personal and family history of cardiomyopathies, aortopathies and arryhtmias, genetic counseling approaches, and testing issues.
Q620 HUMAN CYTOGENETICS (3 cr.)
Consent of the instructor and basic genetics. Study of chromosome structure and replication, X-inactivation, meiosis, numerical and structural rearrangements in human and Cytogenetics of malignancies.
Q621 HUMAN CYTOGENETICS LABORATORY (3 cr.)
Basic Genetics, Q620, and consent of the instructor. Current techniques in human Cytogenetics. May be taken concurrently with Q620.
Q622 CYTOGENETICS OF MALIGNANCIES (3 cr.)
Consent of the instructor. This course will examine the biologic implications of cytogenetic abnormalities found in malignancies. Aberrant gene function as a result of cytogenetic abnormalities will be stressed.
Q623 DYSMORPHOLOGY FOR GENETIC CLINICIANS (1 cr.)
Study of human congenital malformations, deformations, disruptions and dysplasias; review of associated syndromes; approach to dysmorphology evaluation.
Q624 CLINICAL MANAGEMENT AND GENETICS OF METABOLIC DISEASE (1 cr.)
The student will gain a practical understanding of inborn errors of metabolism, the management of patients with these diseases and the genetic counseling issues that arise in the care of families with these diseases.
Q625 INTRODUCTION TO CLINICAL GENETICS (1 cr.)
This class will introduce the students to the broad areas of practice in clinical genetics, the ethical, legal, and social issues involved in the care of patients and families with genetics disorders, and the interface of clinical genetics and genetics research. Students may not take Q625 if they already have taken Q610.
Q629 EMBRYOLOGY FOR GENETIC CLINICIANS (2 cr.)
Normal human conception and embryonic/fetal development and factors causing birth defects.
Q630 POPULATION GENETICS (3 cr.)
Basic genetics. Basic probability and Bayes theorem, as applied to genetic counseling. Effects of mutation and selection on the survival of alleles in a population; consequences of consanguinity and inbreeding; methods of analysis including segregation and linkage including nonparametric methods; quantitative genetics such as twin studies and heritability.
Q631 QUANTITATIVE GENETICS (3 cr.) [Currently inactive]
G651 and G652: Introduction to Biostatistics I and II or equivalent. Inheritance of human quantitative traits, partitioning of phenotypic variation, estimation of genetic variance and heritability, methods of analyzing resemblance among relatives including nuclear families, twins, and half-siblings.
Q640 SPECIALTY TOPICS IN MEDICAL & MOLECULAR GENETICS (1 cr.)
Study of advanced topics/literature not already emphasized in MGEN-Q580, problem-based learning, and skills helpful for the PhD program (grant writing, examination preparation, etc.).
Q642 DERMATOGLYPHICS (2 cr.) [Currently Inactive]
Consent of the instructor. Formation, development, classification, and variation of finger, palm, and footprint patterns (dermatoglyphics) in human; interpretation of results of quantitative and statistical techniques utilized in the study of the inheritance of dermatoglyphic traits, variation in twins, and applications in clinical genetics.
Q660 MEDICAL GENETICS SEMINAR (1 cr.)
Basic genetics. Topics chosen from aspects of medical genetics not extensively treated elsewhere. Various phases of research in medicine from a genetic and clinical point of view. Students may receive credit during each semester or residence on the Medical Center campus.
Q730 METHODS IN HUMAN GENETICS (3 cr.) [Currently Inactive]
Basic genetics, differential calculus, and probability. Sampling methods employed in study of human genetics; methods for analysis of segregation, linkage, mutation, and selection with family data collected under various forms of ascertainment.
Q731 (BIOS688) Theory in Statistical Genetics (3 cr.)
Consent of the instructor, prerequisite: graduate level statistics courses (such as B527, B546, and B636) and Q730. Training in statistical theory used in genetic analyses. In particular, students will understand the rationale underlying differing methods employed to estimate haplotypes, detect association between molecular markers and disease susceptibility or drug response and gene-gene interaction analyses. Cross-referenced with BIOS688.
Q800 MEDICAL GENETICS RESEARCH (cr. arr.)
G504 INTRODUCTION TO RESEARCH ETHICS (2-3cr.)*
Introduction to the basic concepts of research ethics. The course will cover historical development of concern with ethics in science as well as practical information needed by students working in science today. Format will be lecture and discussion.
B651-B652 INTRODUCTION TO BIOSTATISTICS I-II (3-3 cr.)
Data description, sampling variation and distributions, interval estimation, and tests of hypotheses involving binomial, normal t, F, and X 2 distribution; one-way analysis of variance, bivariate regression and correlation, higher order experimental designs, and associated analysis of variance; use of statistical analysis programs on computer.
G716 BIOMEDICAL SCIENCES II - MOLECULAR BIOLOGY AND GENETICS (3 cr.)
Second of three biomedical science courses intended for incoming doctoral students in the School of Medicine or other graduate students. Topics covered include DNA structure and replication, recombination and repair, genomics and processes of inheritance, gene expression, eukaryotic systems, and molecular genetics and disease.
G724 MOLECULAR CANCER GENETICS (1 cr.)
An introduction to cancer focusing on genetics. Topics include causes and effects of chromosome instability (including centromere/telomere failures and chromosomal translocations), epigenetic changes and genetic risk factors during cancer progression.
G725 GENE TRANSFER APPROACHES TO CLINICAL AND BASIC RESEARCH (Gene Therapy) (1 cr.)
A lecture-based course of basic principles involved with the transfer and expression of genetic material. Focus on technical aspects of each vector system, followed by applications to human diseases/experimental animal models. Practical understanding of non-viral and viral gene transfer to utilize these techniques in research studies.
G726 DEVELOPMENTAL GENETICS (1 cr.)
This introductory course focuses on the genetic basis of mouse development. It covers the principles of embryogenesis and explores the mechanism of morphogenic signaling and transcriptional control of body plan and tissue differentiation. Special emphasis will be placed on the role of developmental genetics in understanding human disease.
G727 ANIMAL MODELS OF HUMAN DISEASE (1 cr.)
This class explores advantages and limitations of animal models of human disease. Topics include models for diabetes, psychiatric disorders, cancer, osteoporosis, polycystic kidney and cardiovascular disease. The goal of this course is to provide a framework for students to select experimental animal models in their future research careers.
G746 CHROMOSOME INSTABILITY AND DISEASE (1 cr.)
Exploration of the explore mechanisms of chromosome instability and the clinical impact of this problem. Topics will include chromosome structure and function and how failures in these functions promote chromosome instability in meiosis and mitosis. Other topics include the clinical consequences of chromosome instability in miscarriage, birth defects and cancer.
G788 INTRODUCTION TO NEXT GENERATION SEQUENCING (3 cr.)
Understanding the basic principles of next generation sequencing technology. This includes basic biological applications, basics in data processing, statistical and informatics theories in data analysis, advantages, limitations, and assumptions of different methodologies, and biological interpretation of the results.
G901 ADVANCED RESEARCH (6 cr.)
For Ph.D. students who have at least 90 credit hours. May be taken for maximum of six semesters.