Bryan Hainline, M.D., Ph.D.

Director, Division of Clinical and Biochemical Genetics,
Medical Director, Indiana University Genetic Counseling Program

Dr. Hainline received his MD and PhD degrees at Duke University, North Carolina.  Dr. Hainline completed his pediatric internship and residency at the St. Louis Children's Hospital, St. Louis, Missouri. He underwent fellowship training in clinical, biochemical and molecular genetics at Washington University School of Medicine. He is board certified by the American Board of Pediatrics, and the American Board of Medical Genetics, with certification in Clinical Genetics, and Biochemical/Molecular Genetics.

He is a member of several professional societies including the American Association for the Advancement of Science, American Society of Human Genetics, American College of Medical Genetics, Founding Fellow, Society for the Study of Inborn Errors of Metabolism, American Academy of Pediatrics, American Medical Association, Indiana State Medical Association, Indianapolis Medical Society and on the clinical advisory board of the Prader-Willi Syndrome Association (USA).  He serves on several advisory committees for the Indiana State Board of Health concerning Newborn screening and clinical genetics.


Kelly, D.P., Kim, J.J., Biladello, J.J., Hainline, B.E., Chu, T.W., and Strauss, A.W.  Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci USA 84:4068, 1987.

Heidenreich, R., Natowicz, M., Hainline, B.E., Berman, P., Kelley, R.I., Hillman, R.E., and Berry, G.T.  Acute extrapyramidal syndrome in methylmalonic acidemia:  "Metabolic stroke" involving the globus palidus. J Peds 113:1022, 1988.

Flye, M.W., Riely, C.A., Hainline, B.E., Sassa, S., Gusberg, R.J., Blakemore, K.J., Barwick, K.W., Hanto, D.W., and Horwich, A.L.  The effects of early treatment of hereditary tyrosinemia type I in infancy by orthotopic liver transplantation. Transplanta­tion 49:916-921, 1990.

Hainline, B.E., Kahlenbeck, D.J., Grant, J., and Strauss, A.W.  Tissue specific and developmental expression of rat long-chain acyl-CoA dehydrogenase.  Biochimica et Biophysica Acta 1216:460-468, 1993..

Thacker, M.J., Hainline, B.E., St. Dennis-Feezle, L., Johnson, N.B., and Pescovitz, O.H.  Growth failure in Prader-Willi syndrome is Secondary to Growth Hormone Deficiency.  Hormone Research 49:216-220, 1998.

Vladitiu, G. D., Hainline, B.E., Lethal Neonatal and Severe Late Infantile Forms of Carnitine Palmitoyltransferase II Deficiency associated with compound heterozygosity for different protein truncation mutations. J Pediatr. Nov; 141(5):734-6, 2002. PMID: 12410208

Pan, Z., Gu, H., Talaty, N., Chen, H., Hainline, B. E., Cooks, R.G. and Raftery, D. Principal Component Analysis of Urine Metabolites Detected by NMR and DESI-MS in Patients with Inborn Errors of Metabolism,  Analytical and Bioanalytical Chemistry, 2006.

Shanaiah, N, Desilva, A., Gowda, G. A. N., Raftery, M. A., Hainline, B. E., Raftery, D. Class selection of amino acid metabolites in body fluids using chemical derivatization and their enhanced 13C NMR. Proc. Natl. Acad. Sci USA 104: (28) 11540; 2007.

Clay, A.S. and Hainline B. E., Hyperammonemia in the Intensive Care Unit.  Chest. 132:1368-1378, 2007.

Dimmock, D, Maranda, B, Dionisi-Vici, C, Wang,J, Kleppe, S, Fiermonte, G, Bai, R, Hainline, B. E., Hamosh, A, O'Brien, W. E, Scaglia,F, Wong,L-J, Citrin deficiency, a perplexing global disorder, Molecular Genetics and Metabolism 96: 44-49 2009.

Gu, H,, Pan, Z., Bowei, X., Hainline, B.E., Shanaiah, N., Asiago, V., Gowda, G.A.N., Raftery, D. "H1 NMR metabolomics study of age profiling in children." NMR in Biomedicine 22:1-8 2009.

Lewis KA, Engle W. Hainline, B.E., Johnson, N., Corkins, M. , Eugster, EA. Neonatal Graves Disease Associated with Severe Metabolic Abnormalities, Pediatrics 128(1):e232-6 2011.

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