Yue Wang, Ph.D.
Yue Wang, Ph.D.
Assistant Research Professor of Medical and Molecular Genetics
Bone-marrow derived mesenchymal stem cells (MSCs) have emerged as a promising candidate for cell-based therapy of ischemic heart disease. MSCs are safe, can be easily isolated and amplified from patients’ bone marrow, are immunologically tolerated as transplants, and possess multilineage differentiation potential. Intramyocardial injection of MSCs reduces inflammation, fibrosis, infarct size, ventricular remodeling, and therefore, improves cardiac function. However, these benefits are modest and may have limited duration. Dr. Wang’s laboratory is interested in understanding how MSCs function to protect heart from ischemia and how to maximize their therapeutic potential by developing novel and effective pharmacological and molecular interventions. Such knowledge could lead to better therapies for the ischemic heart diseases and the ischemic insult of other organ systems.
Selected Published articles
- Wang Y, Nicol GD, Clapp DW, and Hingtgen CM. Sensory neurons from Nf1 haploinsufficient mice exhibit increased excitability. J Neurophysiol 94: 3670-3676, 2005.
- Wang M, Crisostomo PR, Markel TA, Wang Y, and Meldrum DR. Mechanisms of sex differences in TNFR2-mediated cardioprotection. Circulation 118: S38-45, 2008.
- Wang Y, Crisostomo PR, Wang M, Markel TA, Novotny NM, and Meldrum DR. TGF-alpha increases human mesenchymal stem cell-secreted VEGF by MEK- and PI3-K- but not JNK- or ERK-dependent mechanisms. Am J Physiol Regul Integr Comp Physiol. 295: R1115-1123, 2008
- Markel TA, Wang Y (co-first author), Herrmann JL, Crisostomo PR, Wang M, Novotny NM, Herring CM, Tan J, Lahm T, and Meldrum DR. VEGF is critical for stem cell-mediated cardioprotection and a crucial paracrine factor for defining the age threshold in adult and neonatal stem cell function. Am J Physiol Heart Circ Physiol. 295: H2308-2314, 2008.
- Wang Y, Wang M, Abarbanell AM, Weil BR, Herrmann JL, Tan J, Novotny NM, Coffey AC, and Meldrum DR. MEK mediates the novel cross talk between TNFR2 and TGF-EGFR in enhancing vascular endothelial growth factor (VEGF) secretion from human mesenchymal stem cells. Surgery 146: 198-205, 2009.
- Wang Y, Weil BR, Herrmann JL, Abarbanell AM, Tan J, Markel TA, Kelly ML, and Meldrum DR. MEK, p38, and PI-3K mediate cross talk between EGFR and TNFR in enhancing hepatocyte growth factor production from human mesenchymal stem cells. Am J Physiol Cell Physiol. 297: C1284-1293, 2009.
- Wang M, Tan J, Wang Y, Meldrum KK, Dinarello CA, and Meldrum DR. IL-18 binding protein-expressing mesenchymal stem cells improve myocardial protection after ischemia or infarction. PNAS. 106: 17499-17504, 2009.
- Wang Y, Duan JH, Hingtgen CM, and Nicol GD. Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/(-) mice. J Neurophysiol.103: 2085-2094, 2010.
- Wang Y, Abarbanell AM, Herrmann JL, Weil BR, Manukyan MC, Poynter JA, and Meldrum DR. TLR4 inhibits mesenchymal stem cell (MSC) STAT3 activation and thereby exerts deleterious effects on MSC-mediated cardioprotection. PloS one 5: e14206, 2010.
- Luo Y, Wang Y (co-first author), Poynter JA, Manukyan MC, Herrmann JL, Abarbanell AM, Weil BR, and Meldrum DR. Pretreating mesenchymal stem cells with interleukin-1beta and transforming growth factor-beta synergistically increases vascular endothelial growth factor production and improves mesenchymal stem cell-mediated myocardial protection after acute ischemia. Surgery 151: 353-363, 2012.
- Xu B, Luo Y, Liu Y, Li BY, and Wang Y (Corresponding author). Platelet-derived growth factor-BB enhances MSC-mediated cardioprotection via suppression of miR-320 expression. Am J Physiol Heart Circ Physiol 308: H980-989, 2015.
- Zhou A, Li M, He B, Feng W, Huang F, Xu B, Dunker AK, Balch C, Li B, Liu Y and Wang Y (corresponding author). Lipopolysaccharide treatment induces genome-wide pre-mRNA splicing pattern changes in mouse bone marrow stromal stem cells, BMC Genomics, in press (2016)