Indiana University

Lang Li, Ph.D.

  • B.A. 1991 - Wuhan University of Technology
  • M.A. 1996 - University of New Mexico
  • Ph.D. 2001 - University of Michigan
  • Research Assistant (1996) Department of Mathematics and Statistics, University of New Mexico
  • Research Assistant (1997-2001) Comprehensive Cancer Center, University of Michigan

Lab Website:

The laboratory research focuses are translational biomedical informatics, pharmacometrics, pharmacogenetics, and system biology.


Li L, Shi H, Yiannoutsos C, Huang Tim and Nephew K. Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system. Journal of Computational Biology. 2005, 12, 370-390.

Li L., Cheng A. S. L., Jin V., Paik H. H., Fan M., Li X., Zhang W., Robarge J., Balch K., Davuluri R. V., Kim S., Huang T., Nephew K. A Mixture Model Based Discriminate Analysis for Identifying Ordered Transcription Factor Binding Site Pairs in Gene Promoters Directly Regulated by Estrogen Receptor-a. Bioinformatics, 2006, 22: 2210-2216.

Li L., Yu M., Chin R., Lucksiri A., Flockhart A. D., and Hall D. S. Drug-drug interaction prediction: a Bayesian meta-analysis approach. 2007, Statistics in Medicine 2007, 26, 3700 - 3721. NIHMS 17357990.

Li L, Hui S, Desta Z, Todd S, Nguyen A and Flockhart D. Estimating a positive false discovery rate for variable selection in pharmacogenetic studies. Journal of Pharmaceutical Statistics, 2007, 17, 883-902.

Desta Z., Saussele T, Ward B., Blievernicht J., Li L., Klein K., Flockhart D. A., Zanger U. M. Impact of CYP2B6 polymorphism on efavirenz metabolism in vitro. Pharmacogenomics. 2007, 8, 547-558.

Robarge J. D., Li L., Desta Z., Nguyen A., and Flockhart D. A. Evaluating genetic nonmenclature of drug metabolizing enzyme. Journal of Clinical Pharmacology and Therapeutics, 2007, 82, 244-248.

Yu M., Kim S, Wang Z., Hall D. S. and Li L. A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction. Journal of Biopharmaceutical Statistics, 2008 18, 1063-1083.

Shen C., Wang Z., Shanker G., Zhang X., and Li L. A Hierarchical Statistical Model to Assess the Confidence of Peptides and Proteins Inferred from Tandem Mass Spectrometry. Bioinformatics, 2008, 24, 202-208.

Feng W., Liu Y., Wu J., Nephew K.P., Huang T., Li L. A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. BMC Genomics, 2008, 9, s23.

Li L., Yu M., Robarge J., Gao S., Jin Y., Borges-Gonzales S., Nguyen A., Skaar T., Desta Z., McLeod H., Sweeney C J., and Flockhart D. A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes. Journal of Biopharmaceutical Statistics, 2008, 18, 1150-1177.

Kim S., Hall S.D., and Li L. A Novel Gibbs Maximum A Posteriori (GMAP) Approach on Bayesian Nonlinear Mixed-Effects Population Pharmacokinetics (PK) Models. Journal of Biopharmaceutical Statistics, 2009, 19, 700-720.

Li L., Borges-Gonzales S, Robarge J., Shen C., Desta Z., and Flockhart D. A Penalized mixture model approach in genotype/phenotype association analysis for quantitative phenotype. Cancer Informatics, Cancer Informatics, 2010, 9, 93-103.

Miao J., Jin Y., Marunde R.L., Kim S., Quinney S., Radovich M., Li L., and Hall S.D. Association of Genotypes of the CYP3A Cluster with Midazolam Disposition In Vivo. Pharmacogenomics Journal, 2009, 9, 319-326.

Borges S., Desta Z., Jin Y., Faouzi A., Robarge J.D., Philip S., Nguyen A., Stearns V., Hayes D., Rae J.M., Skaar T., Flockhart D.A., and Li L. A Composite Functional Genetic and Co-Medication CYP2D6 Activity Score In Predicting Tamoxifen Drug Exposure Among Breast Cancer Patient. Journal of Clinical Pharmacology 2010, 50, 450-458.

Wang Z, Kim S, Quinney SK, Guo Y, Hall SD, Rocha LM, Li L. Literature mining on pharmacokinetics numerical data: a feasibility study., J Biomed Inform. 2009, 42, 725-735.

Wang Z., Kim S., Quinney SK., Zhou J., and Li L. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis - a multivariate nonlinear mixed model. BMC System Biology, 2010, 4, 1 - 8.

Kim S. and Li L. A novel global search algorithm for nonlinear mixed effect models using particle swarm optimization. Journal of Pharmacokinetics and Pharmacodynamics. 2011, 38, 471-495. PMID: 21717235.

Shen C, Huang Y, Liu Y, Wang G, Zhao Y, Wang Z, Teng M, Wang Y, Flockhart DA, Skaar TC, Yan P, Nephew KP, Huang TH, Li L. A Modulated Empirical Bayes Model for Identifying Topological and Temporal Estrogen Receptor α Regulatory Networks in Breast Cancer. BMC Syst Biol. 2011 May 9; 5(1):67.

Kim S. and Li L. A switching Markov chain Monte Carlo method for statistical identifiability of nonlinear pharmacokinetics models. Statistics in Sinica, 2011 (in press).