Indiana University
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Lang Li, Ph.D.

Professor
  • B.A. 1991 - Wuhan University of Technology
  • M.A. 1996 - University of New Mexico
  • Ph.D. 2001 - University of Michigan

Lab Website: http://compbio.iupui.edu/group/13/pages/about_us

Center for Computational Biology and Bioinformatics Website: http://compbio.iupui.edu/.

Indiana Institute of Personalized Medicine: http://medicine.iupui.edu/iipm/.

Dr. Lang Li’s research focuses are drug interaction and pharmacogenomics. His lab uses statistics, biomedical informatics, pharmacometrics, and system pharmacology approaches to investigate drug interactions and genomics effects on drug efficacies and adverse drug events.

PUBLICATIONS

Li L, Brown M, Lee K. and Gupta S.  Estimation and inference for a spline-enhanced nonlinear population pharmacokinetic model. Biometrics, 2002; 58, 601-611.

Li L., Yu M., Chin R., Lucksiri A., Flockhart A. D., and Hall D. S. Drug-drug interaction prediction: a Bayesian meta-analysis approach. 2007, Statistics in Medicine 2007, 26, 3700 - 3721.

Robarge J. D., Li L., Desta Z., Nguyen A., and Flockhart D. A. Evaluating genetic nonmenclature of drug metabolizing enzyme. Journal of Clinical Pharmacology and Therapeutics, 2007, 82, 244-248.

Li L., Yu M., Robarge J., Gao S., Jin Y., Borges-Gonzales S., Nguyen A., Skaar T., Desta Z., McLeod H., Sweeney C J., and Flockhart D. A mixture model approach in gene-gene and gene-environmental interactions for binary phenotypes. Journal of Biopharmaceutical Statistics, 2008, 18, 1150-1177.

Borges S., Desta Z., Jin Y., Faouzi A., Robarge J.D., Philip S., Nguyen A., Stearns V., Hayes D., Rae J.M., Skaar T., Flockhart D.A., and Li L. A Composite Functional Genetic and Co-Medication CYP2D6 Activity Score In Predicting Tamoxifen Drug Exposure Among Breast Cancer Patient. Journal of Clinical Pharmacology 2010, 50, 450-458.

Wang Z, Kim S, Quinney SK, Guo Y, Hall SD, Rocha LM, Li L. Literature mining on pharmacokinetics numerical data: a feasibility study., J Biomed Inform. 2009, 42, 725-735.

Wang Z., Kim S., Quinney SK., Zhou J., and Li L. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis - a multivariate nonlinear mixed model. BMC System Biology, 2010, 4, 1 - 8.

Quinney S.K., Mohammed A. N., Herbert M.F., Hass D.M., Clark S., Umans J.G., Caritis S.N., and Li L. A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy:  Predicting Changes in Midazolam and Nifedipine Pharmacokinetic. CPT: Pharmacometrics and System Pharmacology 2012, 1, e2.

Duke J., Han X., Wang Z., Overhage M., Subhadarshini A., Karnik SD, Rocha L.M., Li X., Strother M., Flockhart D., Quinney SK, and Li L. Literature based drug interaction discovery and its validation in the electronic medical record system. PLoS Computational Biology, 2012, 8(8):e1002614.

Wu H., Karnik S.D., Subhadarshini A., Wang Z., Philips S., Han X., Chiang C., Liu L., Boustani M., Rocha L.M., Flockhart D., Quinney S.K., Li L. An Integrated Pharmacokinetics Ontology and Corpus for Text Mining. BMC Bioinformatics, 2013, 14:35.