Lang Li, Ph.D.

  • B.A. 1991 - Wuhan University of Technology
  • M.A. 1996 - University of New Mexico
  • Ph.D. 2001 - University of Michigan

Lab Website:

Center for Computational Biology and Bioinformatics Website:

Indiana Institute of Personalized Medicine:

Dr. Lang Li’s research focuses are drug interaction and pharmacogenomics. His lab uses statistics, biomedical informatics, pharmacometrics, and system pharmacology approaches to investigate drug interactions and genomics effects on drug efficacies and adverse drug events.


1. Schneider BP, Li L, Radovich M, Shen F, Miller KD, Flockhart DA, Jiang G, Vance G, Gardner L, Vatta M, Bai S, Lai D, Koller D, Zhao F, O'Neill A, Smith ML, Railey E, White C, Partridge A, Sparano J, Davidson NE, Foroud T, Sledge GW Jr. Genome-Wide Association Studies for Taxane-Induced Peripheral Neuropathy in ECOG-5103 and ECOG-1199. Clin Cancer Res. 2015 Nov 15;21(22):5082-91. PMID: 26138065.

2. Zhang P, Du L, Wang L, Liu M, Cheng L, Chiang CW, Wu HY, Quinney SK, Shen L, Li L. A Mixture Dose-Response Model for Identifying High-Dimensional Drug Interaction Effects on Myopathy Using Electronic Medical Record Databases. CPT Pharmacometrics Syst Pharmacol. 2015 Aug;4(8):474-80. PMID: 26380156; PMCID: PMC4562126.

3. Goswami CP, Cheng L, Alexander PS, Singal A, Li L. A New Drug Combinatory Effect Prediction Algorithm on the Cancer Cell Based on Gene Expression and Dose-Response Curve. CPT Pharmacometrics Syst Pharmacol. 2015 Feb;4(2):e9. PMID: 26225234; PMCID: PMC4360667.

4. Han X., Quinney SK, Wang Z., Zhang P., Duke J., Desta Z., Elmendorf JS, Flockhart DA, Li L. Identification and mechanistic investigation of drug-drug interactions associated with myopathy – A translational approach. Clinical Pharmacology and Therapeutics. 2015. 150, 98, 321-7. PMID: 25975815. PMCID: PMC4664558.

5. Schelleman H, Han X, Brensinger CM, Quinney SK, Bilker WB, Flockhart DA, Li L, and Hennessy S. Pharmacoepidemiologic and in vitro evaluation of potential drug-drug interactions of sulfonylureas with fibrates and statins. Br J Clin Pharmacol. 2014 Sep;78(3):639-48. PubMed PMID: 24548191; PubMed Central PMCID: PMC4243914. (Li L. is the co-senior author).

6. Bansal M, Yang J, Karan C, Li L, and NCI-DREAM consortium. Predictive activity of drug combinations through crowdsourcing. Nature Biotechnology, 2014, 32, 1213-22. PMID: 25419740; PMCID: PMC4399794.

7. Wu H, Karnik SD, Subhadarshini A, Wang Z, Philips S, Han X, Chiang C, Liu L, Boustani M, Rocha LM, Flockhart DA, Quinney SK, and Li L. An integrated pharmacokinetics ontology and corpus for text mining. BMC Bioinformatics. 2013 Feb 1;14:35. PubMed PMID: 23374886; PubMed Central PMCID: PMC3571923.

8. Duke J, Han X, Wang Z, Overhage M, Subhadarshini A, Karnik SD, Rocha LM, Li X, Strother M, Flockhart D, Quinney SK, and Li L. Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions. PLoS Comput Biol. 2012;8(8):e1002614. PubMed PMID: 22912565; PubMed Central PMCID: PMC3415435.

9. Quinney SK, Mohammed AN, Herbert MF, Hass DM, Clark S, Umans JG, Caritis SN, and Li L. A semi-mechanistic metabolism model of CYP3A substrates in pregnancy:  Predicting changes in midazolam and nifedipine pharmacokinetic. CPT: Pharmacometrics and System Pharmacology, 2012, 1(9): 1-9.

10.  Kim S and Li L. A novel global search algorithm for nonlinear mixed effect models using particle swarm optimization. Journal of Pharmacokinetics and Pharmacodynamics, 2011, 38: 471-495.

11.  Shen C, Huang Y, Liu Y, Wang G, Zhao Y, Wang Z, Teng M, Wang Y, Flockhart DA, Skaar TC, Yan P, Nephew KP, Huang TH, and Li L. A modulated empirical bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer. BMC Systems Biology, 2011, 9; 5(1): 67.

12.  Wang Z, Kim S, Quinney SK, Zhou J, Li L. Non-compartment model to compartment model pharmacokinetics transformation meta-analysis--a multivariate nonlinear mixed model. BMC Syst Biol. 2010 May 28;4 Suppl 1:S8. PubMed PMID: 20522258; PubMed Central PMCID: PMC2880414.

13.  Wang Z, Kim S, Quinney SK, Guo Y, Hall SD, Rocha LM, and Li L. Literature mining on pharmacokinetics numerical data: a feasibility study. Journal of Biomedical Informatics, 2009, 42: 725-735.

14.  Li L, Cheng AS L, Jin V, Paik HH, Fan M, Li X, Zhang W, Robarge J, Balch K, Davuluri RV, Kim S, Huang T, and Nephew K. A mixture model based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-a. Bioinformatics, 2006, 22: 2210-2216.

15.  Li L, Shi H, Yiannoutsos C, Huang Tim, and Nephew K. Epigenetic hypothesis tests for methylation and acetylation in a triple microarray system. Journal of Computational Biology, 2005, 12: 370-390.

16.  Li L, Brown M, Lee K. and Gupta S.  Estimation and inference for a spline-enhanced nonlinear population pharmacokinetic model. Biometrics, 2002, 58: 601-611.

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