Tatiana Foroud, Ph.D.
P. Michael Conneally Professor of Medical and Molecular Genetics
Director of Hereditary Genomics Division
- B.S. 1987 - Fairfield University
- M.S. 1989 - The University of California, Los Angeles
- Ph.D. 1994 - Indiana University School of Medicine
The central focus of research in Dr. Foroud’s laboratory is the identification of genes contributing to disease. Ongoing studies are focusing on a variety of disorders including Parkinson disease, Alzheimer disease, intracranial aneurysms, alcohol dependence, and cancer. The tools that are currently being employed for gene identification include the genomewide association approach which evaluates millions of SNPs throughout the genome to identify relatively common variants contributing to disease susceptibility. Another approach being utilized with increasing frequency is sequencing – currently of the exome – to identify rare variants that have large effects on disease risk. Dr. Foroud’s research group utilizes statistical approaches to analyze the large amounts of data being generated.
Dr. Foroud also teaches two of the courses in the Hereditary Genomics Division: Q628: Fundamentals of Population Genetics and Q630: Population Genetics.
Foroud T, Sauerbeck L, Brown R, Anderson C, Woo D, Kleindorfer D, Flaherty ML, Deka R, Hornung R, Meissner I, Bailey-Wilson JE, Langefeld C, Rouleau G, Connolly ES, Lai D, Koller DL, Huston J, Broderick JP, FIA Study Investigators. Genome screen in familial intracranial aneurysm. BMC Medical Genetics 10:3, 2009.
Pankratz N, Wilk JB, Latourelle JC, DeStefano AL, Halter C, Pugh EW, Doheny KF, Gusella JF, Nichols WC, Foroud T, Myers RH. The PSG-PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories. Genomewide association study for susceptibility genes contributing to familial Parkinson disease. Human Genetics 124:593-605, 2009.
Koller DL, Ichikawa S, Lai D, Padgett LR, Doheny KF, Pugh EW, Paschall J, Hui SL, Edenberg HJ, Xuei X, Peacock M, Econs MJ, Foroud T. Genome-Wide Association Study of Bone Mineral Density in Premenopausal European-American Women and Replication in African-American Women. Journal of Clinical Endocrinology and Metabolism 95(4):1802-1809, 2010.
Edenberg HJ, Koller DL, Xuei X, Wetherill LF, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI, Rice JP, Schuckit MA, Taylor R, Webb BT, Tischfield JA, Porjesz B, Foroud T. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcoholism: Clinical and Experimental Research 34(5):840-852, 2010.
Klingenberg CP, Wetherill L, Rogers J, Moore E, Ward R, Autti-Ramo I, Fagerlund A, Jacobson SW, Robinson L, Hoyme G, Mattson SN, Li T-K, Riley E, Foroud T, CIFASD Consortium. Prenatal alcohol exposure alters the patterns of facial asymmetry. Alcohol 44(7-8):649-657, 2010